It is revealed that the Black Scrawl isn't actually a virus, but a malfunction of a Replicant's body caused by the relapsing of their correspondent Gestalt. When the Gestalt is fully relapsed, the Replicant of that Gestalt cannot be recreated by the Replicant System again as it can't retrieve the Replicant's data from the gestalt.
Yonah's Replicant will always have the Black Scrawl due to her half-relapsed Gestalt being kept in stasis.
- The Black Scrawl may be a reference to the Black Death (Bubonic Plague), a deadly disease.
- The Black Scrawl resembles the magical runes that emit from both The Dragon and the The Giant in branch E of Drakengard during the final battle in Tokyo.
- The four Angelic Script characters that compose the Black Scrawl are Aleph, Cheth, Gimel and Thes, or A, C, G, and T. These characters likely represent the DNA nucleobases of Adenine, Cytosine, Guanine, and Thymine, indicating that the Black Scrawl represents the breakdown of a Replicant's DNA.