Ordinarily, all Gestalts that were created immediately relapsed. Thanks to the discovery of the Original Gestalt and the distribution of his maso, other Gestalts can assume a stabilized state. This would later be an inaccurate assumption due to the Original Gestalt's corrupted DNA and a bug in Project Gestalt.
The corruption appears to only affect a conscious soul, so the effects can be paused through cold sleep.
If a Replicant is created from a relapsed Gestalt, they will inevitably be affected by the Black Scrawl. Once a Gestalt has relapsed, they can never return to their Replicant.